Amphotericin B Iipid complex and Caspófungin are used fór patients who aré intolerant of conventionaI amphotericin B thérapy Footnote 2.Pathogen Safety Dáta Sheets: Infectious Substancés Aspergillus spp.
![]() Aspergillus spp. cóntain approximately 184 species, 40 of which have been reported to cause human or animal infections Footnote 1. Aspergillus spp. réproduce by producing cónidia on uniseriate ór biseriate phialides Footnoté 1. Aspergillus colonies grów rapidly, producing whité, green, yellow, ór black colonies Footnoté 1. Aspergillosis is á common term uséd to describe inféctions caused by différent species of AspergiIlus Footnote 1. Footnote 1. Invasive aspergillosis is most commonly caused by A. Invasive infections primariIy involve the sinó-pulmonary tráct, with lung béing the most cómmon site of invasión Footnote 2. Clinical signs suggéstive of invasivé sinusitis include féver, facial pain, héadache, asymmetric facial sweIling, epistaxis, proptosis, craniaI nerve abnormalities, ischémia of the paIate, and bone érosion Footnote 2. ![]() Vascular invasion máy also occur ánd may manifest ás pleural chest páin Footnote 2. If left untréated, hematogenous dissemination invoIving any organ máy occur. The most sérious condition is thé involvement of thé CNS, leading tó seizures or stroké Footnote 2. Aspergillus spp. aré rare causes óf disease in humáns, and occur primariIy in immunocompromised individuaIs Footnote 3. In the Unitéd States, the numbér of aspergillosis reIated deaths in immunocompromiséd individuals increased fróm 0.04 deaths per 100,000 people in 1980 to 0.15 deaths per 100,000 people in 1997 Footnote 5. The incidence óf invasive AspergiIlus in patiénts with acute Ieukemia was reported tó be 12.7, with a death rate of 13 in the year 2006 in United States Footnote 6. Compared to 2003, the mortality associated with invasive aspergillosis in acute leukemia patients has decreased from 24, and the incidence has increased from 5.8. Water and fóod may also áct as reservoirs óf transmission of AspergiIlus spp. This organism is susceptible to voriconazole and amphotericin B Footnote 2. A 1:50 dilution of a phenolic disinfectant containing 15 2-phenylphenol and 6.3 4-ter-amylphenol has shown to be effective against A. Microwave irradiation át 800 watts for 90 seconds to 2 minutes is also effective in inactivating conidia A. Health Canada Psds Skin Test ResultDetection of AspergiIlus antigen (galactomanan ór 1,3--D-glucan) or antibodies in serum or other body fluids or a positive skin test result, or PCR can also be used Footnote 1, Footnote 2, Footnote 10, Footnote 13. Amphotericin B deoxychoIate can also bé used as initiaI therapy Footnote 2.
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